A dataset containing groups, descriptions and notes about each amino acid subtype identified in the deep mutational landscape. Groups were determined by ER profile correlation and descriptions/notes from manual assessment of subtype position properties (ER, FoldX predicitons, conservation, etc.).
subtypes
A data frame with 119 rows and 5 columns
Wild type amino acid
Amino acid subtype
Proportion of amino acid positions in the original dataset that are classified into this cluster
Subtype group
Description of the subtype
Additional notes about positions of this subtype
Normalised fitness score when mutating to alanine
Normalised fitness score when mutating to cysteine
Normalised fitness score when mutating to aspartate
Normalised fitness score when mutating to glutamate
Normalised fitness score when mutating to phenylalanine
Normalised fitness score when mutating to glycine
Normalised fitness score when mutating to histidine
Normalised fitness score when mutating to isoleucine
Normalised fitness score when mutating to lysine
Normalised fitness score when mutating to leucine
Normalised fitness score when mutating to methionine
Normalised fitness score when mutating to asparagine
Normalised fitness score when mutating to proline
Normalised fitness score when mutating to glutamine
Normalised fitness score when mutating to arginine
Normalised fitness score when mutating to serine
Normalised fitness score when mutating to threonine
Normalised fitness score when mutating to valine
Normalised fitness score when mutating to tryptophan
Normalised fitness score when mutating to tyrosine
Mean normalised ER fitness score
Mean SIFT4G score for positions of this cluster
Mean FoldX total ddG for mutations to position of this cluster
Mean FoldX backbone_hbond term
Mean FoldX sidechain_hbond term
Mean FoldX van_der_waals term
Mean FoldX electrostatics term
Mean FoldX solvation_polar term
Mean FoldX solvation_hydrophobic term
Mean FoldX van_der_waals_clashes term
Mean FoldX entropy_sidechain term
Mean FoldX entropy_mainchain term
Mean FoldX cis_bond term
Mean FoldX torsional_clash term
Mean FoldX backbone_clash term
Mean FoldX helix_dipole term
Mean FoldX disulfide term
Mean FoldX electrostatic_kon term
Mean FoldX partial_covalent_bonds term
Mean FoldX energy_ionisation term
Mean relative surface accessibility